It is seen most frequently on the lower extremities of young to middleaged adults. Cutaneous, reactive histiocytosis is an immune dysfunction, mainly of young dogs and probably due to persistent antigenic stimulation by a variety of antigens foreign proteins. Most subcutaneous tumours occur on the extremities. Diagnostic approach to malignant fibrous histiocytomas of. For this reason radical surgery with surgical margins of 23 cm is absolutely required. Atypical fibrous histiocytoma immunohistochemistry. Benign fibrous histiocytoma of the tongue priya n s, rao k.
Lipidfilled cells may be conspicuous and occasionally are the major component. Pathology outlines deep benign fibrous histiocytoma. Benign fibrous histiocytoma of bone is a benign primary bone neoplasia characterized by a mixture of fibroblasts disposed in a predominant storiform fashion, a variable amount of osteoclasttype giant cells, foamy macrophages, hemosiderin, and chronic inflammatory infiltrate, a histologic picture indistinguishable from nonossifying fibroma, from which it distinguishes. Benign fibrous histiocytoma of the oralperioral regions. It is fleshcolored and hard and somewhat painful if touched. Benign fibrous histiocytoma is a rare tumor of mesenchymal origin. Langerhans cell histiocytosis histiocytosis x is sometimes associated with cancer, and computed tomography ct scans and biopsies should be done to rule out malignancy. Benign fibrous histiocytoma bfh is a wellestablished softtissue neoplasm that was first described by stout and lattes in 1967. After 4 days in the post operative period, he was discharged. Dermatofibroma, also known as fibrous histiocytoma, is one of the most common cutaneous softtissue lesions, accounting for approximately 3% of skin lesion specimens received by dermatopathology laboratories. A histiocytoma is a benign, firm, rounded or button shaped skin mass of young dogs, usually less than 2 years of age.
Do 1college of veterinary medicine and veterinary science research institute, konkuk university, seoul, republic of korea. V it was first introduced in 1961 by kauffman and stout. Langerhans cell histiocytosis lch adult histiocyte disorders are rare diseases. Generally the prognosis is good, and can be totally resected management, as reported local recurrence is low. Successful treatment of advanced malignant fibrous. Malignant fibrous histiocytoma bone cancer home page. Department of radiotherapy, the university of texas, m. Cutaneous reactive histiocytosis is an uncommon condition of dogs.
Nonlangerhans cell histiocytosis may also be called class ii. Malignant fibrous histiocytoma by jorden grieff on prezi. Malignant fibrous histiocytoma of the prostate capsule urologe a 1985. Malignant fibrous histiocytoma of bone associated with type1 neurofibromatosis. The involvement of the oral cavity is extremely rare and very few cases have been reported in literature till date. Malignant fibrous histiocytoma of the mandible sciencedirect. Malignant fibrous histiocytoma mfh is a soft tissue sarcoma mainly occurring in the soft tissues, especially in the extremities and trunk, and other less common sites include the retroperitoneum, and the head and neck. Niemeyer philipp, karl ludwig, mathias werner et al. Malignant fibrous histiocytoma mfh is the most common malignant soft tissue tumor, but axillarys mfh is extremely rare. Malignant fibrous histiocytoma is a condition involving a tumor of the bone or soft tissues. Generalized eruptive histiocytoma also known as eruptive histiocytoma, and generalized eruptive histiocytosis is a rare cutaneous condition characterized by widespread, erythematous, essentially symmetrical papules, particularly involving the trunk and proximal extremities 717 see also. About histiocytosis danafarber cancer institute boston, ma. Finally, a literature revision of this pathology at the level of the oral.
Apr 06, 2018 fibrous histiocytoma is an infrequent type of sarcoma of uncertain basis that appears both in bone and soft tissue. A case report article pdf available in veterinarni medicina 5012. Malignant fibrous histiocytoma of the mandible akira matsumoto,1 mitsuyoshi matsuda,1 hirofumi harada,1 masanori takekawa,1 taiichi nishimura,2 shinji shimazu3 1department of oral and maxillofacial surgery, asahikawa medical college, 2department of oral and maxillofacial surgery, asahikawa city hospital, and. Finally, a literature revision of this pathology at the level of the oral cavity is reported. Thirtyeight soft tissue tumors including atypical fibroxanthoma n 5, benign fibrous histiocytoma fh n 17 and malignant fibrous histiocytoma mfh n 16 were examined using immunohistochemistry to determine mib1, dna flow cytometry, and p53 pab 1801 immunostaining. Neuropathology of cns disease in langerhans cell histiocytosis nicole grois,1 daniela prayer,2 helmut prosch,1 hans lassmann3 and the cns lch cooperative group correspondence. Benign fibrous histiocytoma questions and answers on benign fibrous histiocytoma suggest treatment for painful lump near elbow. Benign fibrous histiocytomas bfh of the skin are common lesions, although they only rarely involve the oral mucosa. Note the polyhedral to round cells in the dermis and the elongated downgrowth of the epidermis epidermal pegs into the histiocytoma a common feature of these. The tumor often appears in the legs or arms, but it can develop in other parts of the body. The benign fibrous histiocytoma bfh is a mesenchymal tumour that has been described as a benign neoplasm composed of fibroblasts and histiocytes arising in the cutaneous soft tissues. The tumor typically appears between the ages of 50 and 70.
Nicole grois, md, langerhans cell histiocytosis study reference center, children cancer research institute, st anna childrens hospital, kinderspitalgasse 6, a1090. Very few cases of oral involvement of this lesion have been reported till date. Malignant fibrous histiocytoma mfh was first described in the early 1960s and became widely accepted as a specific softtissue sarcoma type in the 1970s. V in 2002, the world health organization who renamed it as an y, nos.
The tumour occurs across a wide age range, rarely in children. Full text successful treatment of advanced malignant. Benign fibrous histiocytoma, ask a doctor about diagnosis, treatment and medication for benign fibrous histiocytoma. Fibrous histiocytoma is an infrequent type of sarcoma of uncertain basis that appears both in bone and soft tissue. Histiocytosis diagnosis and treatment barrow pituitary. The cells that are involved in cutaneous histiocytoma are histiocytes. The fingerlike extensions of mfh in the fatty tissue are responsible not only for the high local recurrence rate, but also increase the metastatic potential and affect the prognosis.
An enlarging painless mass may develop in tumors of soft tissues. The cystoscopic appearance of the malignant fibrous histiocytoma in the prostatic urethra. They generally pop up and grow quickly for a month or so then stop growing and gradually shrink down and resolve on their own without any treatment. Know the types, causes, signs, symptoms, treatment, prevention, prognosis, and complications of fibrous histiocytoma. Benign fibrous histiocytoma, ask a doctor about diagnosis. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. This tumor is seen as a solitary firm cutaneous nodule in a broad age range 5 to 79 years. A biopsy revealed the tumor was a rare malignant fibrous histiocytoma mfh.
Fibrous histiocytoma fh is a common dermal lesion characterized histologically by a proliferation of mononuclear, spindleshaped, or histiocytoid cells andor multinucleated cells, usually admixed with inflammatory cells. Reclassification and subtyping of socalled malignant fibrous. Clinical presentation includes osteolysis, ulcerations of skin and soft tissues but also involvement of the cns is described. The term nonlangerhans cell histiocytosis refers to a group of conditions called histiocytoses that are caused by an overgrowth of cells called histiocytes. Atypical fibrous histiocytoma and atypical fibroxanthoma. Malignant fibrous histiocytoma mfh radiation therapy.
The lesions often arise in the superficial tissues such as skin and rarely involve deeper tissues. Reconstruction of the pelvic ring using an autologous free nonvascularized fibula graft in a patient with benign fibrous histiocytoma. Many clinicopathologic variants of fh have been described including. Pdf deep benign fibrous histiocytoma in the oral cavity. We report our experience with a 75yearold woman with mfh in axilla. Symptoms of histiocytosis because histiocytosis is a systemic disease and can affect any part of the body, it can cause a wide range of symptoms. In their early stages, over the first 14 weeks, they grow rapidly. Dec 17, 2009 fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. V malignant fibrous histiocytoma mfh, a type of sarcoma, is a malignant neoplasm of uncertain origin that arises both in soft tissue and bone. Benign fibrous histiocytoma is an interesting and challenging entity even in its most usual, cutaneous presentation. Jul 14, 2011 atypical fibrous histiocytoma is a rare variant of cutaneous fibrous histiocytoma also called pseudosarcomatous fibrous histiocytoma or dermatofibroma with monster cells 3, 4.
Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib. They are composed of two cell types, namely atypical fibroblasts and histiocytes, arranged in a storiform pattern. Fibrous histiocytoma is of 2 types which includes benign and malignant. All structured data from the file and property namespaces is available under the creative commons cc0 license. Malignant fibrous histiocytoma mfh of the spleen is extremely rare. Reclassification and subtyping of socalled malignant. I am a 56 year old female who has been diagnosed with malignant fibrous histiocytoma a radiation induced soft tissue sarcoma, in january of 1998. Fibrous histiocytoma is a benign soft tissue tumour that may present as a fibrous mass anywhere in the human body. The clinical and histological features of the lesion are reported. Background of classic fibrous histiocytoma including epidermal hyperplasia, grenz zone, spindle cells with storiform pattern and entrapped thick collagen bundles, especially at periphery variable multinucleated giant cells, often with bizarre nuclei monster cells, am j dermatopathol 1987. Brain neuropathology of cns disease in langerhans cell. Atypical fibrous histiocytoma, pseudosarcomatous fibrous histiocytoma, dermatofibroma with monster cells clinical features this is a relatively uncommon lesion. Generalized eruptive histiocytoma also known as eruptive histiocytoma, and generalized eruptive histiocytosis is a rare cutaneous condition characterized by widespread, erythematous, essentially symmetrical papules, particularly involving the trunk and proximal extremities.
Treatment of malignant fibrous histiocytoma and atypical. Benign fibrous histiocytoma of bone is a benign primary bone neoplasia characterized by a mixture of fibroblasts disposed in a predominant storiform fashion, a variable amount of osteoclasttype giant cells, foamy macrophages, hemosiderin, and chronic inflammatory infiltrate, a histologic picture indistinguishable from nonossifying fibroma, from which it distinguishes itself by its. Malignant fibrous histiocytoma is the most common softtissue sarcoma of late adult life. Damato gutirrez m 2016 benign fibrous histiocytoma, case report hematol ed ncol, 2016 doi. Nonlangerhans cell histiocytosis has this name to differentiate it from langerhans cell histiocytosis. The most common of these is langerhans cell histiocytosis lch, which affects only a few hundred patients every year in the united states. Benign fibrous histiocytoma fh is a benign tumor composed of fibroblasts and histiocytes in varying proportions. Noncutaneous presentation is extremely limited, even more so for the mucosa of the head and neck area. What is fibrous histiocytomatypescausestreatmentsurgery. Those in deep soft tissues occur in the mediastinum, retroperitoneum. The lesion is mainly epidermal, but may show extension into the superficial subcutis.
Lch results from the bodys overproduction of immature histiocytes, which are a type of white blood immune cell. We herein report such a case, describing the clinical characteristics of the lesion, complete diagnostic evaluation, management, and followup. Here you can learn about the signs and symptoms of. Langerhans cell histiocytosis lch represents a rare benign disorder, previously designated as histiocytosis x, type ii histiocytosis or langerhans cell granulomatosis. Malignant fibrous histiocytoma of bone associated with. This variant was found in two cases in our study and probably represents an endstage of common fibrous histiocytoma. Files are available under licenses specified on their description page.
Multiple subtypes of mfh, including storiformpleomorphic, myxoid, giant cell, and inflammatory variants, were defined. Malignant fibrous histiocytoma mfh is the most common softtissue sarcoma. V 5 2 12 621627 621 diagnostic approach to malignant fibrous histiocytomas of soft tissue in dogs. Because treatment concepts are not well defined the german. Oct, 2011 the diagnostic entity malignant fibrous histiocytoma mfh of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. This is a common benign harmless tumor of histiocytes. Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. The histiocyte group of cells are part of the bodys immune surveillance system. Cutaneous histiocytoma in dogs vca animal hospital. Benign fibrous histiocytoma of subcutaneous tissue, deep soft tissue or parenchymal organs, with no dermal involvement am j surg pathol 1994. Now i go every 3 months for an mri and cat scan at seattle cancer care alliance. The patient, who was referred from a routine to be consulted by the mass of 10x15 cm and 2 years of evolution, was hospitalized and treated by resective surgery without complications, with negative spreading study. A variant of fibrous histiocytoma located in subcutaneous or deep visceral soft tissues epidemiology. Variants of dermatofibroma a histopathological study.
Malignant fibrous histiocytoma of the mandible akira matsumoto,1 mitsuyoshi matsuda,1 hirofumi harada,1 masanori takekawa,1 taiichi nishimura,2 shinji shimazu3 1department of oral and maxillofacial surgery, asahikawa medical college, 2department of oral and maxillofacial surgery, asahikawa city hospital, and 3department of oral and maxillofacial. This tumor is usually found in adult extremities but rarely occurs in deep soft. Benign fibrous histiocytoma portnotes orthopaedicsone. In december of1979 i underwent a full mastectomy, including underarm lymph nodes as a result of breast cancer. The clinical and histological features of the lesion are discussed precisely in. The histiocytoma elevates the epidermal surface and consists of a solid mass of histiocytic cells. Benign fibrous histiocytoma bfh is a mesenchymal tumor which commonly affects the skin of extremities. I have a lump near my elbow that seems to be growing.
Engage your students during remote learning with video readalouds. The diagnostic entity malignant fibrous histiocytoma mfh of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. Malignant fibrous histiocytoma mfh is a rare malignant sarcoma of soft tissues of head and neck region. During this period of rapid growth, they often ulcerate and. Atypical fibrous histiocytoma is a rare variant of cutaneous fibrous histiocytoma also called pseudosarcomatous fibrous histiocytoma or dermatofibroma with monster cells 3, 4. Histologically, bfh of soft tissues and bone shows similar features, but bfh of the bone is rare with less than 100 cases reported worldwide and usually it involves tibia, femur, and pelvic bone. The clinical and histological features of the lesion are. Pleomorphic sarcoma malignant fibrous histiocytoma of. Nov 07, 2018 malignant fibrous histiocytoma mfh was first described in the early 1960s and became widely accepted as a specific softtissue sarcoma type in the 1970s. We here report a case of benign fibrous histiocytoma localized in the oral cavity. Pleomorphic sarcoma malignant fibrous histiocytoma of soft.